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A blog about how-to, internet, social-networks, windows, linux, blogging, tips and tricks.
05 December 2017
Google expands its 3D objects pipeline for AR/VR with the Poly API
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Vidme Shuts Down Because Google and Facebook
Vidme is shutting down, and it’s all the fault of Google and Facebook. The popular online video platform will go offline on December 15th, 2017, at which point all videos will be “permanently deleted from the Vidme servers”. And with that, Google and Facebook’s stranglehold tightens. A Brief History of Vidme Vidme was launched in 2014. It originally offered a simplified take on the idea of online video-sharing, with people able to upload videos anonymously without needing to register. It then evolved into a hybrid of YouTube and Reddit, with curated categories and content creators. The site attracted millions of...
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Google’s newest app stops you burning through your data package
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Target launches its own mobile payments system with debut of ‘Wallet’
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DeepVariant: Highly Accurate Genomes With Deep Neural Networks
Posted by Mark DePristo and Ryan Poplin, Google Brain Team
(Crossposted on the Google Open Source Blog)
Across many scientific disciplines, but in particular in the field of genomics, major breakthroughs have often resulted from new technologies. From Sanger sequencing, which made it possible to sequence the human genome, to the microarray technologies that enabled the first large-scale genome-wide experiments, new instruments and tools have allowed us to look ever more deeply into the genome and apply the results broadly to health, agriculture and ecology.
One of the most transformative new technologies in genomics was high-throughput sequencing (HTS), which first became commercially available in the early 2000s. HTS allowed scientists and clinicians to produce sequencing data quickly, cheaply, and at scale. However, the output of HTS instruments is not the genome sequence for the individual being analyzed — for humans this is 3 billion paired bases (guanine, cytosine, adenine and thymine) organized into 23 pairs of chromosomes. Instead, these instruments generate ~1 billion short sequences, known as reads. Each read represents just 100 of the 3 billion bases, and per-base error rates range from 0.1-10%. Processing the HTS output into a single, accurate and complete genome sequence is a major outstanding challenge. The importance of this problem, for biomedical applications in particular, has motivated efforts such as the Genome in a Bottle Consortium (GIAB), which produces high confidence human reference genomes that can be used for validation and benchmarking, as well as the precisionFDA community challenges, which are designed to foster innovation that will improve the quality and accuracy of HTS-based genomic tests.
open source release of DeepVariant, a deep learning technology to reconstruct the true genome sequence from HTS sequencer data with significantly greater accuracy than previous classical methods. This work is the product of more than two years of research by the Google Brain team, in collaboration with Verily Life Sciences. DeepVariant transforms the task of variant calling, as this reconstruction problem is known in genomics, into an image classification problem well-suited to Google's existing technology and expertise.
| Each of the four images above is a visualization of actual sequencer reads aligned to a reference genome. A key question is how to use the reads to determine whether there is a variant on both chromosomes, on just one chromosome, or on neither chromosome. There is more than one type of variant, with SNPs and insertions/deletions being the most common. A: a true SNP on one chromosome pair, B: a deletion on one chromosome, C: a deletion on both chromosomes, D: a false variant caused by errors. It's easy to see that these look quite distinct when visualized in this manner. |
DeepVariant is being released as open source software to encourage collaboration and to accelerate the use of this technology to solve real world problems. To further this goal, we partnered with Google Cloud Platform (GCP) to deploy DeepVariant workflows on GCP, available today, in configurations optimized for low-cost and fast turnarounds using scalable GCP technologies like the Pipelines API. This paired set of releases provides a smooth ramp for users to explore and evaluate the capabilities of DeepVariant in their current compute environment while providing a scalable, cloud-based solution to satisfy the needs of even the largest genomics datasets.
DeepVariant is the first of what we hope will be many contributions that leverage Google's computing infrastructure and ML expertise to both better understand the genome and to provide deep learning-based genomics tools to the community. This is all part of a broader goal to apply Google technologies to healthcare and other scientific applications, and to make the results of these efforts broadly accessible.
Facebook Launches Messenger Kids for Children
Facebook has launched a new standalone version of Messenger aimed at kids. And it is, rather inevitably, called Messenger Kids. Messenger Kids is designed for children aged between six and 12, with parents being placed in charge of setting up and managing their children’s access. Thanks to the Children’s Online Privacy and Protection Act (COPPA) no one under the age of 13 is allowed to sign up for a Facebook account. Some kids still do sign up, but Facebook has needed a way to reach out to this younger generation without upsetting their parents for some time. A Child-Friendly Version...
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04 December 2017
You can now import your Instagram contacts into Messenger
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9 Ridiculously Addictive Free Mobile Cartoon Games
Cartoons have made you laugh countless times on TV and online, but in game form? That’s right! You might not know it, but your favorite cartoons have been turned into some of the best and most entertaining mobile games on the market. Maybe it’s that classic cartoon style lends itself well to gaming, but these are seriously some of the most entertaining, most addicting, and most satisfying games to play on mobile. Read on to see the absolute best free games on the market fashioned after cartoons. 1. South Park: Phone Destroyer I can’t begin to measure how impressed I...
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Kinin puts aromatherapy in your mouth
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How to Password Protect a PDF: Free and Paid Options
Did you know that you can password protect PDFs? This underused PDF feature is great for when you have to email and sign sensitive forms or contracts. We’ll show you free and professional tools to add a password to your PDF. Do you know of other methods and tools to secure PDFs? Please share in the comments below! How to Password Protect PDFs With Adobe Acrobat Pro DC Adobe Acrobat Pro DC is a full-service PDF creation suite. It’s $14.99 per month after a seven-day free trial. Besides making and editing PDFs, you can password protect PDFs in Adobe Acrobat...
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10 Tips for Building an Audience for Your Live Streaming Channel
With YouTube ads not providing the revenue they once did, many gaming video creators are supplementing their output with live streaming as well. But it’s not quite the same as pre-recorded videos. When playing live, there are some different strategies you should take to retain an audience. But never fear, we have some advice for those looking to create or grow a live streaming channel. Here are 10 tips for growing (and retaining) your live stream audience: 1. Find Trending Games, But Not Oversaturated Ones When starting out with live streaming on Twitch or other platforms, you’ll want to choose new...
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The Sun Exchange funds solar installations with micro-investments and bitcoin
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Should You Use a Window Manager as Your Desktop Environment?
The general look of some operating systems remain the same, regardless of what you do to them. Linux is different in that regard, with a very high level of flexibility at its core. Each computer running it can vary wildly in both looks, and behavior. As such, it’s easy to have something on Linux that’s suited just for you. This can be hard to do though, if you’re not sure what you’re looking for. This applies even more if you’re using something a bit unique. In this case, using a window manager as your desktop environment. If you’re considering this...
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You Should Be Using the Nest App (Here’s Why)
Nest Labs is one of the biggest names in the smart home industry thanks to its iconic Nest Learning Thermostat. Since launching in 2010, the company has released various smart products, including webcams, smoke detectors, security systems, and more. There’s one app you can use to control all of these products: the free Nest app for iOS and Android. But what exactly does the Nest app do? And what features does it offer? Keep reading to find out. Which Devices Are Supported? The Nest app currently supports the following smart home products: Thermostats: Nest Learning Thermostat, Nest Thermostat E Cameras:...
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OnePlus celebrates ‘The Last Jedi’ with a limited edition Star Wars 5T
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Supercharge Your LinkedIn Feed: Follow These 15 Amazing Influencers
We all know LinkedIn as a place to keep on top of your professional network and search for job openings. But there’s plenty more to the platform than just that. One of my favorite features on LinkedIn is being able to follow influencers and thought leaders who are not just sharing interesting links with their followers, but also publishing valuable, insightful content directly on LinkedIn itself. Intrigued? Follow a few of these popular influencers to keep your LinkedIn feed overflowing with fascinating, insightful content from some of the world’s most respected industry leaders. 1. Richard Branson Needing no introduction, Richard...
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Broadcom piles fresh pressure on Qualcomm to talk takeover
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Facebook “Messenger Kids” lets under-13s chat with whom parents approve
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ftcash helps Indian businesses accept cashless payments and loans them money
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Facebook “Messenger Kids” lets under-13s chat with who parents approve
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